Year : 2017  |  Volume : 9  |  Issue : 2  |  Page : 85-90

Estimation of CCL2/MCP-1 levels in serum and gingival crevicular fluid in periodontal health, disease and after treatment – A clinico biochemical study

1 Department of Dentistry, Sri Padmavathi Medical College for Women, SVIMS, Tirupati, Andhra Pradesh, India
2 Department of Periodontics, KMC Hospital, Sadhana Multispeciality Hospital, Divyapur, Auraiyadh, Uttar Pradesh, India
3 Pondicherry Institute of Medical Sciences, Pondicherry, India
4 Department of Periodontics, CKS Teja Institute of Dental Sciences, Tirupati, Andhra Pradesh, India

Correspondence Address:
Dandu S M Babu
Department of Dentistry, Sri Padmavathi Medical College for Women, SVIMS, Tirupati, Andhra Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jofs.jofs_113_17

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Background: The objective of the present study was to evaluate the role of monocyte chemoattractant protein-1 (MCP-1), in periodontal disease (PD) progression and also to investigate the effect of periodontal therapy on MCP-1 concentration in serum and gingival crevicular fluid (GCF). Materials and Methods: Clinical parameters including gingival index, pocket probing depth, and clinical attachment level were recorded for 60 subjects, who divided into four groups. Group I (healthy, n = 20), Group II (gingivitis, n = 20), Group III (chronic periodontitis, n = 20), and Group IV (after treatment group, n = 20). Scaling and root planning (SRP) was performed, and GCF and serum were collected initially and after 12 weeks of treatment. MCP-1 levels were estimated using enzyme-linked immunosorbent assay. Results: The mean MCP-1 concentration in GCF and serum was found to be the highest in Group III, and significantly defers from Groups I, II, and IV. The results of present study also suggest that MCP-1 levels increased progressively in GCF and serum from healthy to periodontitis subjects and levels decreased considerably after SRP. Conclusion: As the PD progresses, there is a substantial increase of MCP-1 concentrations in serum and GCF. The data indicate that high GCF and serum levels of MCP-1 are at a significantly greater risk for the progression of periodontitis. However, controlled, longitudinal studies are needed to confirm this possibility.

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