Year : 2020  |  Volume : 12  |  Issue : 2  |  Page : 107-112

Serum Iron Indices in Patients with Oral Submucous Fibrosis- A Comparative Study

1 Department of Oral and Maxillofacial Pathology, Mar Baselios Dental College and Hospital, Kothamangalam, Kerala
2 Department of Oral and Maxillofacial Pathology, Annoor Dental College and Hospital, Muvatupuzha, Kerala
3 Department of Oral and Maxillofacial Pathology, Annoor Dental College and Hospital, Muvatupuzha, Kerala, India
4 Department of Oral and Maxillofacial Pathology, KMCT Dental College and Hospital, Kozhikode, Kerala
5 Department of Oral and Maxillofacial Pathology, Thai Moogambigai Dental College and Hospital, Dr MGR Educational and Research Institute University

Correspondence Address:
Dr. Deepu George Mathew
Professor and Head, Department of Oral and Maxillofacial Pathology, Annoor Dental College and Hospital, Muvatupuzha, Kerala
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jofs.jofs_272_20

Rights and Permissions

Introduction: Oral submucous fibrosis (OSMF) is a potentially malignant disorder whose etiopathogenesis is still under investigation. Studies have reported altered serum iron levels in patients with OSMF. Hence, iron has been proposed to play an important role in the incidence and progression of the disease. This study was undertaken to understand the role of iron in the etiopathogenesis of OSMF by estimating haemoglobin and serum iron indices (serum iron, Total iron binding capacity [TIBC], percentage transferrin saturation and serum ferritin) in subjects with OSMF. Materials and Methods: Study group comprised of patients with histopathologically confirmed OSMF (n = 30). Age and sex matched subjects with clinically normal mucosa were selected as control group (n = 15). Hemoglobin, serum ferritin, serum iron, and TIBC were estimated (Siemens Dimension RXL Max Integrated chemistry system™). Statistical analysis used: SPSSv16 was used for statistical analysis. Independent sample t test was performed to compare the values between the study group and control group. ‘p’ value less than 0.05 was considered to be statistically significant. Results: There was a significant decrease in the haemoglobin, serum iron percentage transferrin saturation, serum ferritin levels and an increase in TIBC levels in the study (OSMF) group when compared to the control group (P < 0.001). TIBC levels showed a significant (P< 0.001) increase in the study group. Among the study group 44% were in an anemic state as per the hemoglobin values. Conclusion: The findings of the present study suggest that, iron deficiency state is prevalent among patients with OSMF. This deficiency of iron has an important role in the pathogenesis and progression of this disease.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded57    
    Comments [Add]    

Recommend this journal