ORIGINAL ARTICLE
Year : 2021  |  Volume : 13  |  Issue : 1  |  Page : 67-72

Antifungal Efficacy of Wrightia tinctoria (Roxb.) R.Br on Candida Species Isolated from the Oral Cavity: an Invitro Study


1 Postgraduate Student, Department of Oral and Maxillofacial Pathology, Adhiparasakthi Dental College and Hospital, Melmaruvathur, Tamilnadu, India
2 Associate Professor, Department of Microbiology, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, India
3 Professor and Head of the Department, Department of Oral and Maxillofacial Pathology, Adhiparasakthi Dental College and Hospital, Melmaruvathur, Tamilnadu, India

Correspondence Address:
Dr. K. V. Devika
Department of Oral and Maxillofacial Pathology, Adhiparasakthi Dental College and Hospital, Melmaruvathur, Tamilnadu-603319
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jofs.jofs_284_20

Rights and Permissions

Introduction: Nature is a valuable source of active ingredients that needs to be explored, especially its utilization in the medical field. Owing to the limited availability of antifungal drugs and also considering their side effects, there is always a constant need for a safe and competent alternative. Wrightia tinctoria, a medicinal tree, has been reported to possess potent antifungal activity against commercially available candida strains [American type culture collection (ATCC) and microbial type culture collection (MTCC)]. This could be beneficial clinically only if its antifungal activity could be proved against candida species isolated from clinical samples as the commercially available candida strains might have lost its pathophysiological characteristics on repeated subcultures. Hence, with this background, we performed this study to determine the antifungal efficacy of the extracts obtained from the leaves of W. tinctoria against the candida species isolated from the oral cavity. The aim of this study was to determine the antifungal efficacy of W. tinctoria on candida species isolated from the oral cavity. Materials and Methods: To determine the antifungal activity, acetone, ethyl acetate, and chloroform extracts of leaves of W. tinctoria were used. The study population consisted of five healthy volunteers above 18 years of age without any harmful habits and five patients at increased risk of candida infection. Saliva samples were collected by oral rinse technique using phosphate buffered saline. Fluconazole was used as a positive control and the antifungal efficacy was determined using disk diffusion method. Kruskal-Wallis test was used to determine the significant difference between the extracts. Results: The mean zone of inhibition of acetone, ethyl acetate, and chloroform extracts of leaves of W. tinctoria was 10.8667, 11.0000, 10.1333 mm, respectively. Conclusion: Acetone, ethyl acetate, and chloroform extracts of W. tinctoria possess antifungal activity against candida species isolated from oral cavity.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed252    
    Printed8    
    Emailed0    
    PDF Downloaded42    
    Comments [Add]    

Recommend this journal